Digestive System

Antispasmodic and Antidiarrheal Activity of Cannabidiol (CBD): Involvement of K⁺ Channels in Intestinal Smooth Muscle

Cristian Vaccarini, Alicia E. Consolini, Darío Andrinolo, Daniela Sedan (November 2025)

Taken together, this study provides solid evidence for the antispasmodic and antidiarrheal effects of purified CBD, demonstrating that its action is not related to blockade of L-type calcium channels. Experiments with potassium channel blockers suggest the involvement of KATP channels, in the antispasmodic effect of CBD. However, further studies using additional specific inhibitors are needed to evaluate the role of other contributing mechanisms.

In the castor oil-induced diarrhea model, CBD showed an antidiarrheal effect comparable to loperamide but without impairing intestinal transit, which could represent a therapeutic advantage.

Finally, future studies should evaluate plant-derived extracts, both rich in neutral CBD and in its acidic form (CBDA), in order to compare their efficacy with purified CBD and validate their potential clinical application in functional gastrointestinal disorders.

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